TMCC2 Polyclonal antibody

• Featured Product
• KD/KO Validated

TMCC2 Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, ELISA

Conjugate

Unconjugated

Publications

3

Cat no : 25042-1-AP

Synonyms

Cerebral protein 11, HUCEP11, KIAA0481, TMCC2

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Validation Data Gallery

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  WB analysis of mouse brain using 25042-1-AP

  mouse brain tissue were subjected to SDS PAGE followed by western blot with 25042-1-AP (TMCC2 Antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

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Tested Applications

• Positive WB detected in: mouse brain tissue

Recommended dilution

• Western Blot (WB): WB : 1:500-1:2000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Published Applications

• KD/KO: See 1 publications below
• WB: See 3 publications below

Product Information

The immunogen of 25042-1-AP is TMCC2 Fusion Protein expressed in E. coli.

• Tested Reactivity: human, mouse, rat
• Cited Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: TMCC2 fusion protein Ag19083
• Full Name: transmembrane and coiled-coil domain family 2
• Calculated Molecular Weight: 709 aa, 77 kDa
• Observed Molecular Weight: 85-90 kDa
• GenBank Accession Number: BC131629
• Gene Symbol: TMCC2
• Gene ID (NCBI): 9911
• RRID: AB_2879866
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

TMCC2 also termed as Cerebral protein 11 or HUCEP11 is a 709 amino acid protein, which is a multi-pass membrane protein and belongs to the TEX28 family. The TMCC2 may have an association with Alzheimer's disease.

Publications

Species	Application	Title
rat	WB	Mol Neurodegener; Cognitive impairment in metabolically-obese, normal-weight rats: identification of early biomarkers in peripheral blood mononuclear cells.; Authors - Margalida Cifre
human,mouse	WB	Int J Mol Sci; Ablation of Tmcc2 Gene Impairs Erythropoiesis in Mice.; Authors - Ranju Kumari ; KO Validated
mouse	WB	Hum Mol Genet; Loss of TMCC2 activates endoplasm reticulum stress and causes auditory hair cell death; Authors - Rui Ren