Product Information
31488-1-PBS targets TMCO3 in IP, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag35012 Product name: Recombinant human TMCO3 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 23-285 aa of BC068515 Sequence: VEHEEVAQRVIKLHRGRGVAAMQSRQWVRDSCRKLSGLLRQKNAVLNKLKTAIGAVEKDVGLSDEEKLFQVHTFEIFQKELNESENSVFQAVYGLQRALQGDYKDVVNMKESSRQRLEALREAAIKEETEYMELLAAEKHQVEALKNMQHQNQSLSMLDEILEDVRKAADRLEEEIEEHAFDDNKSVKGVNFEAVLRVEEEEANSKQNITKREVEDDLGLSMLIDSQNNQYILTKPRDSTIPRADHHFIKDIVTIGMLSLPCG Predict reactive species |
| Full Name | transmembrane and coiled-coil domains 3 |
| Calculated Molecular Weight | 75 kDa |
| Observed Molecular Weight | 70 kDa |
| GenBank Accession Number | BC068515 |
| Gene Symbol | TMCO3 |
| Gene ID (NCBI) | 55002 |
| RRID | AB_3742436 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity Purification |
| UNIPROT ID | Q6UWJ1 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
TMCO3, also known as transmembrane and coiled-coil domains 3 or C13orf11, is a protein-coding gene with functional annotation of probable Na+/H+ antiporter. It belongs to the monovalent cation:proton antiporter-2 (CPA2) family according to the Transporter Classification Database (TCDB) (PMID: 33170213). Most CPA2 family members have similar functions and are involved in ion transport (K+, Na+, and H+) in bacteria, archaea, insects, and plants. Upregulated TMCO3 could act as an oncogenic mediator and promote sorafenib resistance in HCC, providing a potential therapeutic target for HCC treatment (PMID: 36304514).
