TMEM11 Polyclonal antibody

• Featured Product
• KD/KO Validated

TMEM11 Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, ELISA

Conjugate

Unconjugated

Publications

3

Cat no : 16564-1-AP

Synonyms

C17orf35, PM1, PMI, Protein PM1, TMEM11, transmembrane protein 11

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Validation Data Gallery

• 

  WB analysis of human placenta using 16564-1-AP

  human placenta tissue were subjected to SDS PAGE followed by western blot with 16564-1-AP (TMEM11 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

• 

  WB analysis of mouse placenta using 16564-1-AP

  mouse placenta tissue were subjected to SDS PAGE followed by western blot with 16564-1-AP (TMEM11 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

• 

  WB analysis of human placenta using 16564-1-AP

  human placenta tissue were subjected to SDS PAGE followed by western blot with 16564-1-AP (TMEM11 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

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Tested Applications

• Positive WB detected in: human placenta tissue, mouse placenta tissue

Recommended dilution

• Western Blot (WB): WB : 1:500-1:2000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Published Applications

• KD/KO: See 1 publications below
• WB: See 3 publications below

Product Information

16564-1-AP targets TMEM11 in WB, ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Cited Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: TMEM11 fusion protein Ag9839
• Full Name: transmembrane protein 11
• Calculated Molecular Weight: 192 aa, 22 kDa
• Observed Molecular Weight: 22 kDa
• GenBank Accession Number: BC020815
• Gene Symbol: TMEM11
• Gene ID (NCBI): 8834
• RRID: AB_2287468
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

TMEM11, also named as C17orf35 and PM1, belongs to the TMEM11 family. TMEM11 is a mitochondrial inner-membrane protein facing the matrix. It regulates mitochondrial morphogenesis independently of the DRP1/MFN fission/fusion pathways.(PMID:21274005)

Publications

Species	Application	Title
human	WB	Elife; QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology.; Authors - Virginia Guarani
human	WB	EMBO Rep; Inner-membrane proteins PMI/TMEM11 regulate mitochondrial morphogenesis independently of the DRP1/MFN fission/fusion pathways.; Authors - Rival Thomas T ; KD Validated
human	WB	J Cell Biol; The outer mitochondrial membrane protein TMEM11 demarcates spatially restricted BNIP3/BNIP3L-mediated mitophagy; Authors - Mehmet Oguz Gok