TMPRSS11D Polyclonal antibody

• 

  WB analysis using 24634-1-AP

  A-253 cells were subjected to SDS PAGE followed by western blot with 24634-1-AP (TMPRSS11D antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours.

TMPRSS11D Polyclonal Antibody for WB, ELISA

Cat No. 24634-1-AP

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, ELISA

Synonyms

HAT, MAT, RAT

---

Tested Applications

• Positive WB detected in: A-253 cells

Recommended dilution

• Western Blot (WB): WB : 1:1000-1:4000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

24634-1-AP targets TMPRSS11D in WB, ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag17841

  Product name: Recombinant human TMPRSS11D protein

  Source: e coli.-derived, PGEX-4T

  Tag: GST

  Domain: 47-352 aa of BC125195

  Sequence: SYFYRSSFQLLNVEYNSQLNSPATQEYRTLSGRIESLITKTFKESNLRNQFIRAHVAKLRQDGSGVRADVVMKFQFTRNNNGASMKSRIESVLRQMLNNSGNLEINPSTEITSLTDQAAANWLINECGAGPDLITLSEQRILGGTEAEEGSWPWQVSLRLNNAHHCGGSLINNMWILTAAHCFRSNSNPRDWIATSGISTTFPKLRMRVRNILIHNNYKSATHENDIALVRLENSVTFTKDIHSVCLPAATQNIPPGSTAYVTGWGAQEYAGHTVPELRQGQVRIISNDVCNAPHSYNGAILSGML

• Full Name: transmembrane protease, serine 11D
• Calculated Molecular Weight: 418 aa, 46 kDa
• Observed Molecular Weight: 46 kDa
• GenBank Accession Number: BC125195
• Gene Symbol: TMPRSS11D
• Gene ID (NCBI): 9407
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: O60235
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

TMPRSS11D, also known as human airway trypsin-like protease (HAT), is a type II transmembrane serine protease that plays a crucial role in various biological processes, including viral infections and cancer progression. This protease is expressed in the epithelial cells of the respiratory tract and has been implicated in the activation of several viruses, such as SARS-CoV-2. In addition to its role in viral infections, TMPRSS11D has also been involved in cancer progression. High expression levels of TMPRSS11D have been associated with poor overall survival in non-small cell lung cancer. This suggests that TMPRSS11D may contribute to tumor growth and metastasis, making it a potential biomarker and therapeutic target in oncology. (PMID: 28086212, PMID: 40348740)