TIPE3/TNFAIP8L3 Polyclonal antibody

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• TIPE3/TNFAIP8L3 Polyclonal antibody (20693-1-AP)

TIPE3/TNFAIP8L3 Polyclonal Antibody for WB, ELISA

Cat No. 20693-1-AP Copied!

Publications (3)

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Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, IHC, ELISA

Synonyms

TNFAIP8L3, TIPE3, TNF alpha-induced protein 8-like protein 3, TNFAIP8 like protein 3, TNFAIP8-like protein 3

• 

  WB analysis using 20693-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 20693-1-AP (TIPE3/TNFAIP8L3 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy

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Tested Applications

• Positive WB detected in: A549 cells, Jurkat cells, MCF-7 cells, mouse spleen tissue

Recommended dilution

• Western Blot (WB): WB : 1:500-1:1000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

20693-1-AP targets TIPE3/TNFAIP8L3 in WB, IHC, ELISA applications and shows reactivity with human, mouse samples.

• Tested Reactivity: human, mouse
• Cited Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  Peptide

• Full Name: tumor necrosis factor, alpha-induced protein 8-like 3
• Calculated Molecular Weight: 33 kDa
• Observed Molecular Weight: 37 kDa
• GenBank Accession Number: NM_207381
• Gene Symbol: TNFAIP8L3
• Gene ID (NCBI): 388121
• RRID: AB_3085613
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q5GJ75
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

TNFAIP8L3 (tumor necrosis factor alpha-induced protein 8-like protein 3), also known as TIPE3, is a member of the TNFAIP8 family which also include TNFAIP8 (TIPE), TNFAIP8L1 (TIPE1) and TNFAIP8L2 (TIPE2) (PMID: 18455983; 21924498). TNFAIP8L3 is a transfer protein for phosphoinositide second messengers. It is markedly upregulated in human cancer cells and may represent a therapeutic target for treating malignant diseases (PMID: 25242044). This antibody is specific to TNFAIP8L3.

Publications

What published studies show

The TIPE3/TNFAIP8L3 polyclonal antibody (Cat# 20693-1-AP) has 3 citations published in Cell Death Discovery, Cell & Molecular Life Sciences, and Human Molecular Genetics. The associated research fields include colorectal cancer drug resistance via autophagy, epigenetic regulation of TIPE3 in nasopharyngeal carcinoma and Hedgehog signaling, and mitochondrial protein biology involving CHCHD2/CHCHD10 oligomerization.

Automatically generated from the 3 publication citations by Able AI.

• Human
• Mouse
• Rat
• Monkey
• Pig

Species	Application	Title
human	IHC	Cell Death Discov; TIPE3 promotes drug resistance in colorectal cancer by enhancing autophagy via the USP19/Beclin1 pathway; Authors - Chun Chen
human	WB	Cell Mol Life Sci; Epigenetic regulation of TIPE3 in nasopharyngeal carcinoma and its impact on the hedgehog signaling pathway.; Authors - Zhongqiang Cheng ; KD Validated
human	WB	Hum Mol Genet; CHCHD2 accumulates in distressed mitochondria and facilitates oligomerization of CHCHD10.; Authors - Xiaoping Huang