TNKS1BP1 Polyclonal antibody

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  WB analysis using 55323-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 55323-1-AP (TNKS1BP1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

TNKS1BP1 Polyclonal Antibody for WB, ELISA

Cat No. 55323-1-AP

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, ELISA

Synonyms

TAB182

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Tested Applications

• Positive WB detected in: HeLa cells, HepG2 cells, L02 cells, MCF-7 cells

Recommended dilution

• Western Blot (WB): WB : 1:500-1:2000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

55323-1-AP targets TNKS1BP1 in WB, ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  Peptide

• Full Name: tankyrase 1 binding protein 1, 182kDa
• Calculated Molecular Weight: 182 kDa
• Observed Molecular Weight: 182 kDa
• GenBank Accession Number: NM_033396
• Gene Symbol: TNKS1BP1
• Gene ID (NCBI): 85456
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q9C0C2
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

TNKS1BP1, also known as TAB182, is a member of the poly(ADP-ribose) polymerase (PARP) superfamily. It is an anchor polymerase 1 (Tankyrase1) binding protein with a molecular weight of 182 kDa and is widely distributed throughout the cell, including the cell membrane, cytoplasm, and nucleus. TNKS1BP1 functions in both telomere maintenance and DNA damage response. TNKS1BP1 can compete with TRF1 to bind to the multiple binding sites of tankyrase1, potentially interfering with the transport of tankyrase1 from cytoplasm to nucleus and its localization in telomeres, which affects the stability of telomeres (PMID: 28058814, PMID: 39019859, PMID: 39113018).