Product Information
17497-1-PBS targets TNRC6B in WB, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag11644 Product name: Recombinant human TNRC6B protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 675-1029 aa of BC028626 Sequence: EFQPGVPWKGIQNIDPESDPYVTPGSVLGGTATSPIVDTDHQLLRDNTTGSNSSLNTSLPSPGAWPYSASDNSFTNVHSTSAKFPDYKSTWSPDPIGHNPTHLSNKMWKNHISSRNTTPLPRPPPGLTNPKPSSPWSSTAPRSVRGWGTQDSRLASASTWSDGGSVRPSYWLVLHNLTPQIDGSTLRTICMQHGPLLTFHLNLTQGTALIRYSTKQEAAKAQTALHMCVLGNTTILAEFATDDEVSRFLAQAQPPTPAATPSAPAAGWQSLETGQNQSDPVGPALNLFGGSTGLGQWSSSAGGSSGADLAGASLWGPPNYSSSLWGVPTVEDPHRMGSPAPLLPGDLLGGGSDSI Predict reactive species |
| Full Name | trinucleotide repeat containing 6B |
| Calculated Molecular Weight | 1029aa,109 kDa; 1723aa,183 kDa |
| Observed Molecular Weight | 190-200 kDa |
| GenBank Accession Number | BC028626 |
| Gene Symbol | TNRC6B |
| Gene ID (NCBI) | 23112 |
| RRID | AB_3741920 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q9UPQ9 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
TNRC6B (Trinucleotide Repeat Containing 6B) is a key component of the microRNA-induced silencing complex (miRISC), where it functions as a critical scaffold protein in the RNA interference pathway. It interacts directly with Argonaute (Ago) proteins and facilitates the recruitment of additional silencing factors, thereby enabling microRNA-mediated translational repression and mRNA decay. TNRC6B is characterized by multiple functional domains, including an arginine-rich motif for binding Argonaute, a ubiquitin-associated domain, and a glycine-tryptophan repeat region. In addition to its essential role in gene silencing, TNRC6B is also involved in processing bodies (P-bodies) and has been implicated in cellular processes such as development and viral defense. Mutations in the TNRC6B gene have recently been associated with neurodevelopmental disorders, highlighting its importance beyond post-transcriptional regulation.
