Product Information
24760-1-PBS targets TPOR/MPL in WB, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag19035 Product name: Recombinant human MPL protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 27-379 aa of BC153092 Sequence: DVSLLASDSEPLKCFSRTFEDLTCFWDEEEAAPSGTYQLLYAYPREKPRACPLSSQSMPHFGTRYVCQFPDQEEVRLFFPLHLWVKNVFLNQTRTQRVLFVDSVGLPAPPSIIKAMGGSQPGELQISWEEPAPEISDFLRYELRYGPRDPKNSTGPTVIQLIATETCCPALQRPHSASALDQSPCAQPTMPWQDGPKQTSPSREASALTAEGGSCLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCFTLDLKNVTCQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHFKSRNDSIIHILVEVTTAPGTVHSYL Predict reactive species |
| Full Name | myeloproliferative leukemia virus oncogene |
| Calculated Molecular Weight | 635 aa, 71 kDa |
| Observed Molecular Weight | 84 kDa, 74 kDa |
| GenBank Accession Number | BC153092 |
| Gene Symbol | MPL |
| Gene ID (NCBI) | 4352 |
| RRID | AB_2879709 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | P40238 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
The TPOR/MPL protein (thrombopoietin receptor, also known as myeloproliferative leukemia protein) is a type I transmembrane receptor of the hematopoietic growth factor receptor family. It primarily serves as the specific receptor for thrombopoietin (TPO) and regulates hematopoietic stem cell self-renewal, megakaryocyte differentiation, and platelet production by activating multiple downstream signaling pathways including JAK/STAT, PI3K/AKT, and MAPK, thereby playing a central role in maintaining normal hematopoietic homeostasis in the body.
