TPOR/MPL Recombinant monoclonal antibody, PBS Only

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• TPOR/MPL Recombinant monoclonal antibody, PBS Only (86495-3-PBS)

• 

  WB analysis of HEL using 86495-3-RR (same clone as 86495-3-PBS)

  HEL cells were subjected to SDS PAGE followed by western blot with 86495-3-RR (MPL antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86495-3-PBS in a different storage buffer formulation.

• 

  WB analysis of human peripheral blood platelets using 86495-3-RR (same clone as 86495-3-PBS)

  human peripheral blood platelets were subjected to SDS PAGE followed by western blot with 86495-3-RR (MPL antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86495-3-PBS in a different storage buffer formulation.

TPOR/MPL Uni-rAb^® Recombinant Antibody for WB, Indirect ELISA

Cat No. 86495-3-PBS

Clone No.251731G4

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Synonyms

CD110, MPL, Myeloproliferative leukemia protein, Proto-oncogene c-Mpl, Thrombopoietin receptor

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Product Information

86495-3-PBS targets TPOR/MPL in WB, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen:

  DNA

• Full Name: myeloproliferative leukemia virus oncogene
• Calculated Molecular Weight: 635 aa, 71 kDa
• Observed Molecular Weight: 84 kDa, 74 kDa
• GenBank Accession Number: BC153092
• Gene Symbol: MPL
• Gene ID (NCBI): 4352
• RRID: AB_3744925
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: P40238
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

The TPOR/MPL protein (thrombopoietin receptor, also known as myeloproliferative leukemia protein) is a type I transmembrane receptor of the hematopoietic growth factor receptor family. It primarily serves as the specific receptor for thrombopoietin (TPO) and regulates hematopoietic stem cell self-renewal, megakaryocyte differentiation, and platelet production by activating multiple downstream signaling pathways including JAK/STAT, PI3K/AKT, and MAPK, thereby playing a central role in maintaining normal hematopoietic homeostasis in the body.