TPX2 Monoclonal antibody, PBS Only

TPX2 Monoclonal Antibody for WB, IF/ICC, Indirect ELISA

Cat No. 68712-1-PBS
Clone No.2E10C1

Host / Isotype

Mouse / IgG2b

Reactivity

human, mouse, rat

Applications

WB, IF/ICC, Indirect ELISA

2E10C1, C20orf1, C20orf2, Differentially expressed in cancerous and non-cancerous lung cells 2, DIL 2

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

Freight/Packing: -

Quantity

Please visit your regions distributor:


Product Information

68712-1-PBS targets TPX2 in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Host / Isotype Mouse / IgG2b
Class Monoclonal
Type Antibody
Immunogen TPX2 fusion protein Ag33683 Predict reactive species
Full Name TPX2, microtubule-associated, homolog (Xenopus laevis)
Calculated Molecular Weight 747 aa, 86 kDa
Observed Molecular Weight 98 kDa
GenBank Accession NumberBC020207
Gene Symbol TPX2
Gene ID (NCBI) 22974
Conjugate Unconjugated
FormLiquid
Purification MethodProtein A purification
UNIPROT IDQ9ULW0
Storage Buffer PBS only, pH 7.3.
Storage ConditionsStore at -80°C.

Background Information

TPX2, also known as DIL2, p10, is a microtubule organization- and cell cycle-associated protein. In the early stage of mitosis, TPX2 is released in a RanGTP-dependent manner and plays a significant role in mitotic spindle formation and subsequent proper segregation of chromosomes during cell division. Furthermore, during interphase, TPX2 is involved in DNA damage response by regulation of γ-H2AX signals(PMID: 25914189). Aberrant expression of TPX2 leads to improper spindle assembly and chromosomal instability. Overexpressed in cancers, TPX2 is being established as the marker for the diagnosis and prognosis of malignancies(PMID: 24556998).

Loading...