|Positive WB detected in||Jurkat cells|
|Western Blot (WB)||WB : 1:500-1:1000|
|Sample-dependent, check data in validation data gallery|
13623-1-AP targets TRIM15 in WB, IHC, IF, ELISA applications and shows reactivity with human samples.
|Host / Isotype||Rabbit / IgG|
|Immunogen||TRIM15 fusion protein Ag4533|
|Full Name||tripartite motif-containing 15|
|Calculated molecular weight||465 aa, 52 kDa|
|Observed molecular weight||52 kDa|
|GenBank accession number||BC038585|
|Gene ID (NCBI)||89870|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
TRIM15 (Tripartite motif-containing protein 15) is also named as RNF93, ZNF178, ZNFB7 and belongs to the TRIM/RBCC family. It acts as an ubiquitin-protein ligase and contributes to the endogenous restriction of retroviruses in cells.
Tripartite motif-containing 15 overexpression in non-small cell lung cancer is associated with poor patient prognoses.
TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity.
J Cell Sci
TRIM15 is a focal adhesion protein that regulates focal adhesion disassembly.
Nat Cell Biol
TRIM15 and CYLD regulate ERK activation via lysine-63-linked polyubiquitination.