TRPC5 Polyclonal antibody

TRPC5 Polyclonal Antibody for WB, IF, IHC, ELISA

Host / Isotype

Rabbit / IgG


human, mouse





Cat no : 25890-1-AP


hTRP 5, hTRP5, Transient receptor protein 5, TRP 5, TRP5, TRPC5

Tested Applications

Positive WB detected inHL-60 cells, MCF-7 cells
Positive IHC detected inhuman brain tissue, human cerebellum tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Positive IF detected inSH-SY5Y cells

Recommended dilution

Western Blot (WB)WB : 1:1000-1:4000
Immunohistochemistry (IHC)IHC : 1:50-1:500
Immunofluorescence (IF)IF : 1:10-1:100
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

The immunogen of 25890-1-AP is TRPC5 Fusion Protein expressed in E. coli.

Tested Reactivity human, mouse
Cited Reactivityhuman, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen TRPC5 fusion protein Ag23171
Full Name transient receptor potential cation channel, subfamily C, member 5
Calculated Molecular Weight 111 kDa
Observed Molecular Weight 105 kDa
GenBank Accession NumberBC137271
Gene Symbol TRPC5
Gene ID (NCBI) 7224
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Short transient receptor potential channel 5(TRPC5), which belongs to TRPC5 sub-subfamily of transient receptor (TC 1.A.4) family, thought to form a receptor-activated non-selective calcium permeant cation channel, and probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. TRPC5 has also been shown to be calcium-selective and may also be activated by intracellular calcium store depletion.


Product Specific Protocols
WB protocol for TRPC5 antibody 25890-1-APDownload protocol
IHC protocol for TRPC5 antibody 25890-1-APDownload protocol
IF protocol for TRPC5 antibody 25890-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols



Cancer Lett

TRPC3 promotes tumorigenesis of gastric cancer via the CNB2/GSK3β/NFATc2 signaling pathway.

Authors - Da-Cen Lin


Structural basis for human TRPC5 channel inhibition by two distinct inhibitors.

Authors - Kangcheng Song

J Neuroinflammation

Upregulation of TRPC5 in hippocampal excitatory synapses improves memory impairment associated with neuroinflammation in microglia knockout IL-10 mice.

Authors - Shiji Huo

J Mol Cell Cardiol

TRPV6 protects ER stress-induced apoptosis via ATF6α-TRPV6-JNK pathway in human embryonic stem cell-derived cardiomyocytes.

Authors - Zhichao Li

Biochem Pharmacol

Endothelial cell transient receptor potential channel C5 (TRPC5) is essential for endothelium-dependent contraction in mouse carotid arteries.

Authors - Cai Liang

Biochem Biophys Res Commun

Trpc5-regulated AMPKα/mTOR autophagy pathway is associated with glucose metabolism disorders in low birth weight mice under overnutrition

Authors - Fei Zhou