TSPYL6 Polyclonal antibody, PBS Only

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• TSPYL6 Polyclonal antibody, PBS Only (33274-1-PBS)

• 

  WB analysis of K-562 using 33274-1-AP (same clone as 33274-1-PBS)

  WB result of TSPYL6 antibody (33274-1-AP; 1:4000; incubated at room temperature for 1.5 hours) with sh-Control and sh-TSPYL6 transfected K-562 cells. This data was developed using the same antibody clone with 33274-1-PBS in a different storage buffer formulation.

• 

  WB analysis using 33274-1-AP (same clone as 33274-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 33274-1-AP (TSPYL6 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 33274-1-PBS in a different storage buffer formulation.

• Featured Product
• KD/KO Validated

TSPYL6 Polyclonal Antibody for WB, Indirect ELISA

Cat No. 33274-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Synonyms

Testis-specific Y-encoded-like protein 6, TSPY Like 6, TSPY-like protein 6

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Product Information

33274-1-PBS targets TSPYL6 in WB, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag38157

  Product name: Recombinant human TSPYL6 protein

  Source: e coli.-derived, PGEX-4T

  Tag: GST

  Domain: 1-410 aa of BC068576

  Sequence: MSLPESPHSPATLDYALEDPHQGQRSREKSKATEVMADMFDGRLEPIVFPPPRLPEEGVAPQDPADGGHTFHILVDAGRSHGAIKAGQEVTPPPAEGLEAASASLTTDSSLKNGFPGEETHGLGGEKALETCGAGRSESEVIAEGKAEDVKPEECAMFSAPVDEKPGGEEMDVAEENRAIDEVNREAGPGPGPGPLNVGLHLNPLESIQLELDSVNAEADRALLQVERRFGQIHEYYLEQRNDIICNIPGFWVTAFRHHPQLSAMIRGQDAEMLSYLTNLEVKELRHPRTGCKFKFFFQRNPYFRNKLIVKVYEVRSFGQVVSFSTLIMWRRGHGPQSFIHRNRHVICSFFTWFSDHSLPESDRIAQIIKEDLWSNPLQYYLLGEDAHRARRRLVREPVEIPRPFGFQCG

• Full Name: TSPY-like 6
• Calculated Molecular Weight: 410 aa, 46 kDa
• Observed Molecular Weight: 60 kDa
• GenBank Accession Number: BC068576
• Gene Symbol: TSPYL6
• Gene ID (NCBI): 388951
• RRID: AB_3742922
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity Purification
• UNIPROT ID: Q8N831
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

TSPYL6 (TSPY-like 6) protein is a member of the TSPY-like nucleoprotein family, and its specific physiological function has not yet been fully elucidated. However, this protein has garnered significant attention in cancer research as "an important tumor biomarker". Studies have shown that TSPYL6 is frequently overexpressed in various malignant tumors, such as breast cancer, lung cancer, colorectal cancer, and hepatocellular carcinoma. Its overexpression promotes tumor cell proliferation, invasion, and metastasis, while inhibiting apoptosis, and is closely associated with poor patient prognosis. Mechanistically, TSPYL6 is believed to exert its cancer-promoting effects by influencing cell cycle progression (e.g., promoting the G1/S phase transition) and regulating key oncogenic signaling pathways such as Wnt/β-catenin. Therefore, TSPYL6 is not only a potential diagnostic and prognostic biomarker but also considered a potential therapeutic target for cancer.