TTBK2 Recombinant monoclonal antibody, PBS Only

• 

  WB analysis using 84634-1-RR (same clone as 84634-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 84634-1-RR (TTBK2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84634-1-PBS in a different storage buffer formulation.

• 

  WB analysis of HeLa using 84634-1-RR (same clone as 84634-1-PBS)

  WB result of TTBK2 antibody (84634-1-RR; 1:1000; incubated at room temperature for 1.5 hours) with sh-Control and sh-TTBK2 transfected HeLa cells. This data was developed using the same antibody clone with 84634-1-PBS in a different storage buffer formulation.

• 

  Affinity and Kinetic Characterization of 84634-1-RR

  Biolayer interferometry (BLl) kinetic assays of 84634-1-RR against Human TTBK2 were performed. The affinity constant is 0.14 nM.

• Featured Product
• KD/KO Validated

TTBK2 Uni-rAb^® Recombinant Antibody for WB, Indirect ELISA

Cat No. 84634-1-PBS

Clone No.241456B4

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Synonyms

241456B4, EC:2.7.11.1, KIAA0847, SCA11, tau tubulin kinase 2

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Product Information

84634-1-PBS targets TTBK2 in WB, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen:

  CatNo: Ag7108

  Product name: Recombinant human TTBK2 protein

  Source: e coli.-derived, T-HIS

  Tag: 6*His

  Domain: 1-354 aa of BC071556

  Sequence: MSGGGEQPDILSVGILVKERWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGRQILESIESIHSVGFLHRDIKPSNFAMGRFPSTCRKCYMLDFGLARQFTNSCGDVRPPRAVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPWRKIKDKEQVGSIKERYDHRLMLKHLPPEFSIFLDHISSLDYFTKPDYQLLTSVFDNSIKTFGVIESDPFDWEKTGNDGSLTTTTTSTTPQLHTRLTPAAIGIANATPIPGDLLRENTDEVFPDEQLSD

• Full Name: tau tubulin kinase 2
• Calculated Molecular Weight: 137 kDa
• Observed Molecular Weight: 137-150 kDa
• GenBank Accession Number: BC071556
• Gene Symbol: TTBK2
• Gene ID (NCBI): 146057
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purfication
• UNIPROT ID: Q6IQ55
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

TTBK2(tau tubulin kinase 2) plays an important role in the tau cascade and in spinocerebellar degeneration. The N-terminus of TTBK2 has a serine-threonine-tyrosine kinase domain, and a C-terminal region shows homology to TTBK1. TTBK1 and TTBK2 function as regulators of TDP-43 phosphorylation. TTBK1/2 may be attractive drug targets for therapeutic interventions in TDP-43 proteinopathies such as FTLD-TDP and ALS.(PMID:25473830).