Product Information
20005-1-AP targets transcription termination factor-Specific in IHC, ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Cited Reactivity | mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
Peptide Predict reactive species |
| Full Name | transcription termination factor, RNA polymerase I |
| Calculated Molecular Weight | 103 kDa |
| GenBank Accession Number | NM_007344 |
| Gene Symbol | TTF1 |
| Gene ID (NCBI) | 7270 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q15361 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. |
Background Information
TTF1 is a multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. It plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5, TTF1 recovers DNA-binding activity. The antibody is specific to TTF1. This TTF1 is didderent to another TTF1 (Thyroid transcription factor 1).
Publications
What published studies show
The TTF1 (transcription termination factor) Specific Polyclonal antibody (Cat# 20005-1-AP) has 1 total citation. It was cited in Phytomedicine (Impact Factor: 11.3), in a 2024 study investigating how the Yi-Fei-San-Jie Chinese medicine formula reverses immune escape in lung cancer by regulating deoxycholic acid metabolism and inhibiting the TGR5/STAT3/PD-L1 axis. The antibody was used for IHC in mouse samples, placing the research within the fields of oncology, traditional Chinese medicine, and immune signaling.
| Species | Application | Title |
|---|---|---|
Phytomedicine Yi-Fei-San-Jie Chinese medicine formula reverses immune escape by regulating deoxycholic acid metabolism to inhibit TGR5/STAT3/PD-L1 axis in lung cancer |
