Mouse TrkB Recombinant monoclonal antibody, PBS Only

• 

  WB analysis of mouse brain using 85971-3-RR (same clone as 85971-3-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 85971-3-RR (TrkB antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85971-3-PBS in a different storage buffer formulation.

TrkB Uni-rAb^® Recombinant Antibody for WB, Indirect ELISA

Cat No. 85971-3-PBS

Clone No.250617A8

Host / Isotype

Rabbit / IgG

Reactivity

mouse, rat

Applications

WB, Indirect ELISA

Synonyms

BDNF/NT-3 growth factors receptor, EC:2.7.10.1, GP145-TrkB/GP95-TrkB, Neurotrophic tyrosine kinase receptor type 2, Ntrk2

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Product Information

85971-3-PBS targets TrkB in WB, Indirect ELISA applications and shows reactivity with mouse, rat samples.

• Tested Reactivity: mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen:

  CatNo: Eg3000

  Product name: Recombinant Mouse TrkB protein (rFc Tag) (HPLC verified)

  Source: mammalian cells-derived, V37

  Tag: C-rFc

  Domain: 32-429 aa of NM_001025074.3

  Sequence: CPTSCKCSSARIWCTEPSPGIVAFPRLEPNSVDPENITEILIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAYKAFLKNSNLRHINFTRNKLTSLSRRHFRHLDLSDLILTGNPFTCSCDIMWLKTLQETKSSPDTQDLYCLNESSKNMPLANLQIPNCGLPSARLAAPNLTVEEGKSVTLSCSVGGDPLPTLYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVRGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLMAKNEYGKDERQISAHFMGRPGVDYETNPNYPEVLYEDWTTPTDIGDTTNKSNEIPSTDVADQSNREH

• Full Name: neurotrophic tyrosine kinase, receptor, type 2
• Calculated Molecular Weight: 92 kDa
• Observed Molecular Weight: 90-95 kDa, 140-145 kDa
• GenBank Accession Number: NM_001025074.3
• Gene Symbol: Ntrk2
• Gene ID (NCBI): 18212
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: P15209-1
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

Tropomyosin-related kinase B (TrkB) is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. It is a single-pass type 1 membrane protein consisting of three domains: an extracellular ligand binding domain, a transmembrane domain and an intracellular tyrosine kinase domain. TrkB is primarily expressed in the central and peripheral nervous systems. TrkB plays an important role in neural development and maintenance through regulating neuronal differentiation, proliferation, survival, migration, neurogenesis, and plasticity.