Tested Applications
| Positive WB detected in | NCI-H1299 cells, mouse liver tissue, rat liver tissue, mouse kidney tissue |
Recommended dilution
| Application | Dilution |
|---|---|
| Western Blot (WB) | WB : 1:1000-1:8000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
Product Information
23765-1-AP targets UGT1A6 in WB, ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Cited Reactivity | mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag20635 Product name: Recombinant human UGT1A6 protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 176-488 aa of BC019861 Sequence: CSLEHTFSRSPDPVSYIPRCYTKFSDHMTFSQRVANFLVNLLEPYLFYCLFSKYEELASAVLKRDVDIITLYQKVSVWLLRYDFVLEYPRPVMPNMVFIGGINCKKRKDLSQEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMATADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSL Predict reactive species |
| Full Name | UDP glucuronosyltransferase 1 family, polypeptide A6 |
| Calculated Molecular Weight | 532 aa, 61 kDa |
| Observed Molecular Weight | 70 kDa |
| GenBank Accession Number | BC019861 |
| Gene Symbol | UGT1A6 |
| Gene ID (NCBI) | 54578 |
| RRID | AB_3742089 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | P19224 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. |
Background Information
UDP-glucuronosyltransferase 1-6 (UGT1A6, also known as GNT1 and UGT1) plays a crucial role in the glucuronidation of numerous drugs, toxins, and endogenous substrates. This process is essential for detoxifying and excreting lipophilic compounds, primarily in the liver (PMID: 15761114).
Protocols
| Product Specific Protocols | |
|---|---|
| WB protocol for UGT1A6 antibody 23765-1-AP | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
Publications
What published studies show
The UGT1A6 Polyclonal antibody (Cat# 23765-1-AP) has 3 total citations. These appear in Cell Metabolism, Probiotics and Antimicrobial Proteins, and Clinical and Translational Oncology. The associated research fields include diabetic fragility fractures and bone remodeling, ulcerative colitis with metabolic-immune crosstalk, and pancreatic cancer as a prognostic biomarker and therapeutic target.
| Species | Application | Title |
|---|---|---|
Cell Metab Maltol induces diabetic fragility fractures by disrupting the balance of bone remodeling. | ||
Probiotics Antimicrob Proteins Enterococcus hirae Y-HS Alleviates Ulcerative Colitis by Activating PXR/Nrf2-mediated Metabolic-immune Crosstalk. | ||
Clin Transl Oncol UGT1A6 in pancreatic cancer: a promising prognostic biomarker and therapeutic target |
