VEGFA Recombinant monoclonal antibody, PBS Only

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• VEGFA Recombinant monoclonal antibody, PBS Only (87404-1-PBS)

VEGFA Uni-rAb^® Recombinant Antibody for WB, Indirect ELISA

Cat No. 87404-1-PBS

Clone No.252453F7

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Synonyms

VEGF, L-VEGF, N-VEGF, Vascular Endothelial Growth Factor, vascular endothelial growth factor A

• 

  WB analysis of HUVEC using 87404-1-RR (same clone as 87404-1-PBS)

  HUVEC cells were subjected to SDS PAGE followed by western blot with 87404-1-RR (VEGF121/VEGF165 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 87404-1-PBS in a different storage buffer formulation.

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy

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Product Information

87404-1-PBS targets VEGFA in WB, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen:

  CatNo:

  Product name: HumanKine® recombinant human VEGF121 protein

  Source: -derived,

  Tag:

  Domain: of

  Sequence:

• Full Name: vascular endothelial growth factor A
• Observed Molecular Weight: 27 kDa
• Gene Symbol: VEGFA
• Gene ID (NCBI): 7422
• RRID: AB_3745520
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: P15692
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

VEGFA, also named as VEGF or VPF, belongs to the PDGF/VEGF growth factor family. It is a growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. VEGFA induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. It binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. Defects in VEGFA are associated with microvascular complications of diabetes type 1 (MVCD1). VEGFA has 17 isoforms with MW from 16 to 45 kDa. Some isoforms have homodimer forms (e.g.; VEGFA189 38 kDa or VEFGA110 34 kDa). VEGF-A exists in at least seven homodimeric isoforms. The monomers consist of 121, 145, 148, 165, 183, 189, or 206 amino acids (PMID:15602010 ).