Product Information
20526-1-PBS targets ZC4H2 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag14388 Product name: Recombinant human ZC4H2 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-224 aa of BC004411 Sequence: MADEQEIMCKLESIKEIRNKTLQMEKIKARLKAEFEALESEERHLKEYKQEMDLLLQEKMAHVEELRLIHADINVMENTIKQSENDLNKLLESTRRLHDEYKPLKEHVDALRMTLGLQRLPDLCEEEEKLSLDYFEKQKAEWQTEPQEPPIPESLAAAAAAAQQLQVARKQDTRQTATFRQQPPPMKACLSCHQQIHRNAPICPLCKAKSRSRNPKKPKRKQDE Predict reactive species |
| Full Name | zinc finger, C4H2 domain containing |
| Calculated Molecular Weight | 224 aa, 26 kDa |
| Observed Molecular Weight | 26 kDa |
| GenBank Accession Number | BC004411 |
| Gene Symbol | ZC4H2 |
| Gene ID (NCBI) | 55906 |
| RRID | AB_3742000 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q9NQZ6 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
ZC4H2 is located on the X chromosome, which encodes a C4H2 type zinc-finger nuclear factor. Mutations in ZC4H2 have been reported to be associated with various disorders, including arthrogryposis multiplex congenita (AMC), X-linked intellectual disability, Wieacker-Wolff syndrome, and Miles-Carpenter syndrome . Since ZC4H2 is located on the X-chromosome, the disorder is usually severe or even lethal in males. Mechanistically, ZC4H2 has been shown mostly to work as a stabilizing co-factor of the ubiquitin E3 ligase RNF220. RNF220 and ZC4H2 cooperate to pattern the embryonic ventral neural tube through regulation of Shh/Gli signaling as well as the stability of key transcription factors (Dbx1/2 and Nkx2.2) . (PMID: 31336385, PMID: 39336725)
