|Positive WB detected in
|PC-3 cells, HEK-293T cells, mouse brain tissue
|Positive IP detected in
|Western Blot (WB)
|WB : 1:500-1:2000
|IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate
|It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
|Sample-dependent, check data in validation data gallery
25196-1-AP targets ZCCHC6 in WB, IP, IF, CoIP, ELISA applications and shows reactivity with human, mouse, rat samples.
|human, mouse, rat
|Host / Isotype
|Rabbit / IgG
|ZCCHC6 fusion protein Ag18240
|zinc finger, CCHC domain containing 6
|Calculated molecular weight
|1495 aa, 171 kDa
|Observed molecular weight
|GenBank accession number
|Gene ID (NCBI)
|Antigen affinity purification
|PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
|Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.
ZCCHC6 also named as KIAA1711 ,HS2 or TUT7 is a 1495 amino acid protein, which contains threes CCHC-type zinc fingers and two PAP-associated domains. A member of the DNA polymerase type-B-like family, ZCCHC6 as a uridylyltransferase that mediates RNA uridylation.
Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis.
3' Uridylation Confers miRNAs with Non-canonical Target Repertoires.
A Mechanism for microRNA Arm Switching Regulated by Uridylation.
TENT2, TUT4, and TUT7 selectively regulate miRNA sequence and abundance
AGO-bound mature miRNAs are oligouridylated by TUTs and subsequently degraded by DIS3L2.
The molecular basis of coupling between poly(A)-tail length and translational efficiency.