ZNF768 Polyclonal antibody

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• ZNF768 Polyclonal antibody (33035-1-AP)

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  WB analysis using 33035-1-AP

  HeLa cells lysate was subjected to SDS PAGE followed by western blot with 33035-1-AP (ZNF768 antibody) at dilution of 1:6000 incubated at room temperature for 1.5 hours.

ZNF768 Polyclonal Antibody for WB, ELISA

Cat No. 33035-1-AP

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, ELISA

Synonyms

Zinc finger protein 768

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Tested Applications

• Positive WB detected in: HeLa cells

Recommended dilution

• Western Blot (WB): WB : 1:2000-1:12000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

33035-1-AP targets ZNF768 in WB, ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag37794

  Product name: Recombinant human ZNF768 protein

  Source: e coli.-derived, PGEX-4T

  Tag: GST

  Domain: 1-175 aa of BC013760

  Sequence: MRSPEGYLRGNMSENEEEEISQQEGSGDYEVEEIPFGLEPQSPGFEPQSPEFEPQSPRFEPESPGFESRSPGLVPPSPEFAPRSPESDSQSPEFESQSPRYEPQSPGYEPRSPGYEPRSPGYESESSRYESQNTELKTQSPEFEAQSSKFQEGAEMLLNPDEKSPLNISVGVHPL

• Full Name: zinc finger protein 768
• Calculated Molecular Weight: 60 kDa
• Observed Molecular Weight: 70 kDa
• GenBank Accession Number: BC013760
• Gene Symbol: ZNF768
• Gene ID (NCBI): 79724
• RRID: AB_3742829
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity Purification
• UNIPROT ID: Q9H5H4
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Zinc finger protein 768 (ZNF768) is a zinc finger protein that is crucial in linking oncogenic RAS signaling to cellular senescence and proliferation control. It is a transcription factor that associates with euchromatin and promoter regions of many genes in a cell type-specific manner. ZNF768 is required for cell growth and survival, and its depletion induces a strong proliferative and pro-apoptotic response in several cell lines in vitro. ZNF768 is also involved in regulating cell cycle effectors and p53 targets, with its overexpression sufficient to bypass RAS-induced senescence in a p53-dependent manner (PMID: 34404770; 35419475).