iNOS Recombinant antibody, PBS Only

iNOS Uni-rAbTM Recombinant Antibody for WB, IHC, ELISA
Cat No. 80517-1-PBS
Clone No.6O22

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IHC, ELISA

NOS2, Inducible NOS, Inducible NO synthase, HEP-NOS, Hepatocyte NOS

Formulation:  PBS Only
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

Freight/Packing: -

Quantity

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Product Information

80517-1-PBS targets iNOS in WB, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen Peptide Predict reactive species
Full Name nitric oxide synthase 2, inducible
Calculated Molecular Weight 131 kDa
Observed Molecular Weight110-130 kDa
GenBank Accession NumberNM_000625
Gene Symbol iNOS
Gene ID (NCBI) 4843
RRIDAB_2918898
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDP35228
Storage Buffer PBS only, pH 7.3.
Storage ConditionsStore at -80°C.

Background Information

NOS2, also named as iNOS and NOS2A, produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. NO is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission, antimicrobial and antitumoral activities. NOS2 is a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. iNOS has a very short half-life due to rapid degradation by calpain. iNOS monomer is a direct substrate of calpain I and can be cleaved by calpain I at the canonical CaM-binding site(503-532aa) of iNOS, and then a ~70kD band can be detected by western (PMID:11786228). This antibody is specific to NOS2.

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