• HEK293 expressed
  • Endotoxin-free
  • Animal-component free

HumanKine® recombinant human FGF-9 protein

Activity(Primary)

2-11 ng/mL EC50

Species Reactivity

monkey,human

Purity

>95%

Cat no : HZ-1329

Synonyms

Glia-activating factor (GAF) Heparin-binding growth factor 9 (HBGF-9) Fibroblast Growth Factor-9



Technical Specifications

GeneID 2254
Species Human
Expression HEK293
Activity(Primary) 2-11 ng/mL EC50
Purity >95%
Endotoxin<1 EU/μg
Accession NumberP31371
Molecular Mass 25 kDa monomer, glycosylated
Formulation 1x PBS, See Certificate of Analysis for details
Species Reactivity monkey,human

Stability and Reconstitution

Stability and StorageProduct FormTemperature ConditionsStorage Time
(From Date of Receipt)
Lyophilized-20°C to -80°CUntil Expiry Date
LyophilizedRoom Temperature2 weeks
Reconstituted as per CofA-20°C to -80°C6 months
Reconstituted as per CofA4°C1 week
Avoid repeated freeze-thaw cycles.
Reconstitution Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 1x PBS pH 7.4 containing 0.1% endotoxin-free recombinant human serum albumin (HSA).

Background

FGF-9 is a 26 kdA, glycosylated protein that is a member of the FGF superfamily. It primarily binds with FGFR3 and plays prominent roles in the regulating embryonic, lung, and skeletal development. It is a key regulator of male sex determination through promoting the proliferation of pre-Sertoli cells. It signals in conjunction with FGF-10 and SHH to drive the development of the lung mesenchymal space. FGF-9 is also a positive regulator of chondrocyte proliferation and osteogenesis during the bone formation process. Overexpression of loss of FGF-9 during skeletal development often results in aberrant bone growth. (PMID: 28395336, 25772309, 16540513, 25435023).

Synonyms

Glia-activating factor (GAF) Heparin-binding growth factor 9 (HBGF-9) Fibroblast Growth Factor-9