- HEK293 expressed
- Endotoxin-free
- Animal-component free
HumanKine® recombinant human Activin A protein
Cat no : HZ-1138
Synonyms
Activin A, Activin beta A chain, EDF, FRP, INHBA, Inhibin beta A chain, inhibin, beta A
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Technical Specifications
GeneID | 3624 |
Species | human |
Expression | HEK293 |
Activity | Typically ≤ 5 ng/mL EC50 |
Purity | >95% |
Molecular Mass | 25 kDa, homodimer, non-glycosylated |
Formulation | 1x PBS, See Certificate of Analysis for details |
Species Reactivity | human, mouse |
Stability and Reconstitution
Stability and Storage | Lyophilized proteins are stable for 1 year from the date of receipt if stored between (-20oC) and (-80oC). Upon reconstitution we recommend that the solution can be stored at (4oC) for short term or at (-20oC) to (-80oC) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products. |
Reconstitution | Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 1xPBS containing 0.1% endotoxin-free recombinant human serum albumin (HSA). |
Background
Activin A, a member of the TGF-β superfamily, was named for its ability to activate FSH secretion from the anterior pituitary gland (PMID 16885530). Three activins have been identified in human tissues: activin A, activin B, and activinAB, of which activin A is the most studied. Activin A has various functions in regulating cell differentiation, proliferation, apoptosis and carcinogenesis (PMID 8200957). Xeno-free Recombinant Human Activin A is expressed from human 293 cells as disulfide linked homodimers with molecular mass of 25 kDa.
Synonyms
Activin A, Activin beta A chain, EDF, FRP, INHBA, Inhibin beta A chain, inhibin, beta A
Publications
Species | Title |
---|---|
Protein Cell Modeling CADASIL vascular pathologies with patient-derived induced pluripotent stem cells. | |
Tissue Eng Part C Methods Essential components for ex vivo proliferation of mesenchymal stromal cells. | |
STAR Protoc Protocol for Differentiation of Human iPSCs into Pulmonary Neuroendocrine Cells. | |
Birth Defects Res B Dev Reprod Toxicol Lost in translation: The search for an in vitro screen for spermatogenic toxicity. | |
Eur J Obstet Gynecol Reprod Biol Effects of gremlin-2 on the transition of primordial follicles during early folliculogenesis in the human ovary. |