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  • HEK293 expressed
  • Endotoxin-free
  • Animal-component free

Animal-free Recombinant Human IL-17A

Activity

Typically ≤ 2 ng/mL EC50

Species Reactivity

Human

Purity

>95%

Cat no : HZ-1113

Synonyms

IL-17, CTLA-8 IL17A, IL 17A, IL 17, IL17, CTLA8, CTLA 8



Technical Specifications

GeneID 3605
Species Human
Expression HEK293
Activity Typically ≤ 2 ng/mL EC50
Purity >95%
Molecular Mass 30 to 35 kDa, homodimer
Formulation 10 mM Tris-HCl pH 7.4+ 250 mM NaCl, See Certificate of Analysis for details
Species Reactivity human

Stability and Reconstitution

Stability and Storage Lyophilized proteins are stable for 1 year from the date of receipt if stored between (-20oC) and (-80oC). Upon reconstitution we recommend that the solution can be stored at (4oC) for short term or at (-20oC) to (-80oC) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.
Reconstitution Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 1xPBS containing 0.1% endotoxin-free recombinant human serum albumin (HSA).

Product Description

Animal-free IL-17 (IL-17A) is expressed in human 293 cells as a homodimeric glycoprotein with an apparent molecular mass of 30 to 35 kDa. The IL-17 family is comprised of at least 6 proinflammatory cytokines that share a conserved cystine-knot structure but diverage at the N-terminus. IL-17 family members are glycoproteins secreted as dimers that induce local cytokine production and recruit granulocytes to sites of inflammation.

Background

IL-17 (IL-17A) is a homodimeric glycoprotein with an apparent molecular mass of 30 to 35 kDa. The IL-17 family is comprised of at least 6 proinflammatory cytokines that share a conserved cystine-knot structure but diverge at the N-terminus. IL-17 family members are glycoproteins that induce local cytokine production and recruit granulocytes to sites of inflammation (PMID: 15485625; 11574464).

Synonyms

IL-17, CTLA-8 IL17A, IL 17A, IL 17, IL17, CTLA8, CTLA 8

Publications

SpeciesTitle
human

Acta Otolaryngol

Multiplex analyses of cytokine and chemokine release from the cultured fibroblast of nasal polyps: the effect of IL-17A.

Authors - HirotomoHomma
human

PLoS One

Isolation of All CD44 Transcripts in Human Epidermis and Regulation of Their Expression by Various Agents.

Authors - KwesiTeye
human

Arthritis Rheumatol

Thymidine phosphorylase regulates the expression of CXCL10 in rheumatoid arthritis fibroblast-like synoviocytes.

Authors - YukoToyoda