• HEK293 expressed
  • Endotoxin-free
  • Animal-component free

HumanKine® recombinant human IL-17 (IL-17A) protein

Activity

0.24-1.2 ng/mL EC50

Species Reactivity

human

Purity

>95%

Cat no : HZ-1113

Synonyms

CTLA 8, CTLA8, IL 17, IL 17A, IL17, IL-17, IL17A, IL-17A, interleukin 17A



Technical Specifications

GeneID 3605
Species Human
Expression HEK293
Activity 0.24-1.2 ng/mL EC50
Purity >95%
Endotoxin<1 EU/µg
Accession NumberQ16552
Molecular Mass 30 to 35 kDa, homodimer
Formulation 10 mM Tris-HCl pH 7.4+ 250 mM NaCl, See Certificate of Analysis for details
Species Reactivity human

Stability and Reconstitution

Stability and StorageProduct FormTemperature ConditionsStorage Time
(From Date of Receipt)
Lyophilized-20°C to -80°CUntil Expiry Date
LyophilizedRoom Temperature2 weeks
Reconstituted as per CofA-20°C to -80°C6 months
Reconstituted as per CofA4°C1 week
Avoid repeated freeze-thaw cycles.
Reconstitution Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 1xPBS containing 0.1% endotoxin-free recombinant human serum albumin (HSA).

Background

IL-17 (IL-17A) is a homodimeric glycoprotein with an apparent molecular mass of 30 to 35 kDa. The IL-17 family is comprised of at least 6 proinflammatory cytokines that share a conserved cystine-knot structure but diverge at the N-terminus. IL-17 family members are glycoproteins that induce local cytokine production and recruit granulocytes to sites of inflammation (PMID: 15485625; 11574464).

Synonyms

CTLA 8, CTLA8, IL 17, IL 17A, IL17, IL-17, IL17A, IL-17A, interleukin 17A

Publications

SpeciesTitle
human

Acta Otolaryngol

Multiplex analyses of cytokine and chemokine release from the cultured fibroblast of nasal polyps: the effect of IL-17A.

Authors - HirotomoHomma
human

PLoS One

Isolation of All CD44 Transcripts in Human Epidermis and Regulation of Their Expression by Various Agents.

Authors - KwesiTeye
human

Front Immunol

Therapeutic Effects of (5R)-5-Hydroxytriptolide on Fibroblast-Like Synoviocytes in Rheumatoid Arthritis via lncRNA WAKMAR2/miR-4478/E2F1/p53 Axis.

Authors - Xinpeng Zhou
human

Arthritis Rheumatol

Thymidine phosphorylase regulates the expression of CXCL10 in rheumatoid arthritis fibroblast-like synoviocytes.

Authors - YukoToyoda
human

J Invest Dermatol

Chrna5 is overexpressed in psoriasis patients and promotes psoriasis-like inflammation in mouse models.

Authors - Jing Wang