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  • HEK293 expressed
  • Endotoxin-free
  • Animal-component free

HumanKine® recombinant human IL-28B protein

Activity

0.07-0.35 ng/mL EC50

Species Reactivity

human

Purity

>95%

Cat no : HZ-1245

Synonyms

Cytokine Zcyto22, IFN lambda 3, IFN lambda 4, IFNL3, IFNL4, IFN-lambda 3, IFN-lambda 4, IL 28B, IL 28C, IL28, IL-28, IL28B, IL-28B, IL28C, Interferon lambda 3, Interferon lambda 4, Interleukin 28B, Interleukin 28C, ZCYTO22



Technical Specifications

GeneID 282617
Species human
Expression HEK293
Activity 0.07-0.35 ng/mL EC50
Purity >95%
Endotoxin<1 EU/μg
Accession NumberQ8IZI9
Molecular Mass 24 kDa, monomer, non-glycosylated
Formulation 1x PBS, See Certificate of Analysis for details
Species Reactivity human

Stability and Reconstitution

Stability and Storage Lyophilized proteins are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.
Reconstitution Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 1xPBS containing 0.1% endotoxin-free recombinant human serum albumin (HSA).

Background

IL28B is a type III IFN, which shares many of the biological effects of type I IFNs but may have fewer side effects due to a more selective receptor distribution. It interacts with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA) (PMID: 20712453;12469119;16539846).

Synonyms

Cytokine Zcyto22, IFN lambda 3, IFN lambda 4, IFNL3, IFNL4, IFN-lambda 3, IFN-lambda 4, IL 28B, IL 28C, IL28, IL-28, IL28B, IL-28B, IL28C, Interferon lambda 3, Interferon lambda 4, Interleukin 28B, Interleukin 28C, ZCYTO22

Publications

SpeciesTitle
human

J Virol Methods

Screening of novel drugs for inhibiting hepatitis E virus replication.

Authors - Takashi Nishiyama
human

Cytokine

IFN-λ3 as a host immune response in acute hepatitis E virus infection.

Authors - Kazumoto Murata

Antiviral Res

Antiviral candidates against the hepatitis E virus (HEV) and their combinations inhibit HEV growth in in vitro.

Authors - Takashi Nishiyama