|Activity||Typically ≤ 1 ng/mL EC50|
|Molecular Mass||30 kDa, monomer, glycosylated|
|Formulation||1x PBS, See Certificate of Analysis for details|
Stability and Reconstitution
|Stability and Storage||Product Form||Temperature Conditions||Storage Time|
(From Date of Receipt)
|Lyophilized||-20°C to -80°C||Until Expiry Date|
|Lyophilized||Room Temperature||2 weeks|
|Reconstituted as per CofA||-20°C to -80°C||6 months|
|Reconstituted as per CofA||4°C||1 week|
|Avoid repeated freeze-thaw cycles.|
|Reconstitution||Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 1xPBS containing 0.1% endotoxin-free recombinant human serum albumin (HSA).|
Oncostatin M (OSM) is a member of a cytokine family that includes a leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. OSM is a growth regulator which inhibits the proliferation of some tumor cell lines. It can stimulate proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF, and GM-CSF from endothelial cells. OSM is involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (PMID: 9133674; 29526757; 29363180; 21887386).
oncostatin M, OSM
A Novel Naphthoquinone-Coumarin Hybrid That Inhibits BCR-ABL1-STAT5 Oncogenic Pathway and Reduces Survival in Imatinib-Resistant Chronic Myelogenous Leukemia Cells.
Interleukin-6 and oncostatin M are elevated in liver disease in conjunction with candidate hepatocellular carcinoma biomarker GP73.
CM363, a novel naphthoquinone derivative which acts as multikinase modulator and overcomes imatinib resistance in chronic myelogenous leukemia.
The reviews below have been submitted by verified Proteintech customers who received an incentive forproviding their feedback.
E (Verified Customer) (06-01-2022)
I used protein for hiPSC differentiation in hepatocyte cells and it works well
Toby (Verified Customer) (10-05-2021)
Recombinant Human OSM is used as part of our differentiation protocol, and is involved in the last stage in which we differentiate from a hepatoblast to a hepatocyte like cell. This product worked very well and aided with successful differentiation.
Dongling (Verified Customer) (11-12-2018)