• HEK293 expressed
  • Endotoxin-free
  • Animal-component free

HumanKine® recombinant human OSM protein

Activity

Typically ≤ 1 ng/mL EC50

Species Reactivity

human

Purity

>95%

Cat no : HZ-1030

Synonyms

oncostatin M, OSM



Technical Specifications

GeneID 5008
Species Human
Expression HEK293
Activity Typically ≤ 1 ng/mL EC50
Purity >95%
Endotoxin<1 EU/μg
Accession NumberP13725
Molecular Mass 30 kDa, monomer, glycosylated
Formulation 1x PBS, See Certificate of Analysis for details
Species Reactivity human

Stability and Reconstitution

Stability and StorageProduct FormTemperature ConditionsStorage Time
(From Date of Receipt)
Lyophilized-20°C to -80°CUntil Expiry Date
LyophilizedRoom Temperature2 weeks
Reconstituted as per CofA-20°C to -80°C6 months
Reconstituted as per CofA4°C1 week
Avoid repeated freeze-thaw cycles.
Reconstitution Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 1xPBS containing 0.1% endotoxin-free recombinant human serum albumin (HSA).

Background

Oncostatin M (OSM) is a member of a cytokine family that includes a leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. OSM is a growth regulator which inhibits the proliferation of some tumor cell lines. It can stimulate proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF, and GM-CSF from endothelial cells. OSM is involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (PMID: 9133674; 29526757; 29363180; 21887386).

Synonyms

oncostatin M, OSM

Publications

SpeciesTitle
human

Front Pharmacol

A Novel Naphthoquinone-Coumarin Hybrid That Inhibits BCR-ABL1-STAT5 Oncogenic Pathway and Reduces Survival in Imatinib-Resistant Chronic Myelogenous Leukemia Cells.

Authors - Patricia Martín-Rodríguez
human

Cancer Biomark

Interleukin-6 and oncostatin M are elevated in liver disease in conjunction with candidate hepatocellular carcinoma biomarker GP73.

Authors - HongyanLiang
human

Oncotarget

CM363, a novel naphthoquinone derivative which acts as multikinase modulator and overcomes imatinib resistance in chronic myelogenous leukemia.

Authors - BorjaGuerra

Reviews

The reviews below have been submitted by verified Proteintech customers who received an incentive forproviding their feedback.


FH

E (Verified Customer) (06-01-2022)

I used protein for hiPSC differentiation in hepatocyte cells and it works well

  • Applications: Cell culture
  • Cell Tissue Type: hiPSC
FH

Toby (Verified Customer) (10-05-2021)

Recombinant Human OSM is used as part of our differentiation protocol, and is involved in the last stage in which we differentiate from a hepatoblast to a hepatocyte like cell. This product worked very well and aided with successful differentiation.

  • Applications: Cell culture,Other
  • Cell Tissue Type: Stem cell differentiation
FH

Dongling (Verified Customer) (11-12-2018)

  • Applications: Flow Cytometry,Cell culture,Other,
  • Cell Tissue Type: iPSC's