- HEK293 expressed
- Endotoxin-free
- Animal-component free
HumanKine® recombinant human VEGF121 protein
Activity
Typically ≤ 15 ng/mL EC50
Species Reactivity
human,pig
Purity
>95%
Cat no : HZ-1204
Synonyms
L VEGFA, MVCD1, Vascular permeability factor, VEGF, VEGF A, VEGF121, VEGFA, VPF
Validation Data Gallery
Technical Specifications
GeneID | 7422 |
Species | Human |
Expression | HEK293 |
Activity | Typically ≤ 15 ng/mL EC50 |
Purity | >95% |
Endotoxin | <1 EU/µg |
Accession Number | P15692 |
Molecular Mass | 37 kDa, homodimer; 50 kDa, homotrimer, glycosylated |
Formulation | 1x PBS, See Certificate of Analysis for details |
Species Reactivity | human,pig |
Stability and Reconstitution
Stability and Storage | Product Form | Temperature Conditions | Storage Time (From Date of Receipt) |
---|---|---|---|
Lyophilized | -20°C to -80°C | Until Expiry Date | |
Lyophilized | Room Temperature | 2 weeks | |
Reconstituted as per CofA | -20°C to -80°C | 6 months | |
Reconstituted as per CofA | 4°C | 1 week | |
Avoid repeated freeze-thaw cycles. |
Reconstitution | Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 1xPBS containing 0.1% endotoxin-free recombinant human serum albumin (HSA). |
Background
This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulphide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells and is essential for physiological and pathological angiogenesis. Misregulations of this gene in mice result in abnormal embryonic blood vessel formation (PMID:10838264; 11329058).
Synonyms
L VEGFA, MVCD1, Vascular permeability factor, VEGF, VEGF A, VEGF121, VEGFA, VPF
Publications
Species | Title |
---|---|
Protein Cell Modeling CADASIL vascular pathologies with patient-derived induced pluripotent stem cells. | |
J Exp Clin Cancer Res Retraction Note: Receptor tyrosine kinase inhibitor Sunitinib and integrin antagonist peptide HM-3 show similar lipid raft dependent biphasic regulation of tumor angiogenesis and metastasis. | |
J Stem Cells Regen Med Increased mesodermal and mesendodermal populations by BMP4 treatment facilitates human iPSC line differentiation into a cardiac lineage. | |
NMR Biomed MRI study of cryoinjury infarction in pig hearts: i. Effects of intrapericardial delivery of bFGF/VEGF embedded in alginate beads. | |
Int J Oncol Calpain is involved in cisplatin-induced endothelial injury in an in vitro three-dimensional blood vessel model. | |
Exp Cell Res Recombinant human soluble thrombomodulin attenuates FK506-induced endothelial dysfunction through prevention of Akt inactivation. |