Product Information
98824-2-PBS targets uPA/Urokinase in FC applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Immunogen |
CatNo: Eg7083 Product name: Recombinant human PLAU/uPA protein Source: mammalian cells-derived, pHZ-KIsec-C-rFc Tag: C-rFc Domain: 21-431 aa of NM_002658.6 Sequence: SNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQHCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRNPDNRRRPWCYVQVGLKLLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKEENGLAL Predict reactive species |
| Full Name | plasminogen activator, urokinase |
| Calculated Molecular Weight | 49kDa |
| GenBank Accession Number | NM_002658.6 |
| Gene Symbol | Urokinase |
| Gene ID (NCBI) | 5328 |
| RRID | AB_3746365 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | P00749-1 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
uPA (Urokinase-type plasminogen activator) is also named as Urokinase or PLAU, and belongs to the peptidase S1 family. uPA initiates a proteolytic cascade, which degrades the extracellular matrix during tissue growth and remodelling. The secreted proform of uPA is activated after binding to a specific high-affinity cell surface receptor. Secreted UPA is exposed to rapid inactivation in the pericellular space by plasminogen activator inhibitor-1 (PAI-1), which is stored in the extracellular matrix bound to vitronectin (PMID: 9665342). It has 2 isoforms produced by alternative splicing. Defects in uPA are the cause of Quebec platelet disorder (QPD).
