FlexAble is a site-specific antibody labeling technology designed to make conjugation faster, simpler, and more flexible across multiple applications. In this video, we explain how FlexAble can be used to label antibodies for immunofluorescence, western blotting, flow cytometry, and other workflows without buffer exchange or purification. We also show how its broad buffer compatibility, low antibody input requirements, and same-species multiplexing support make it useful for a wide range of experimental designs.