ACC1 Antibody 10 Publications

Rabbit Polyclonal| Catalog number: 21923-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 79 μg/150 μl

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Species specificity:
human, mouse, rat, pig

Positive WB detected in:
HeLa cells, HEK-293 cells, human brain tissue, PC-3 cells, rat brain tissue

Positive IP detected in:
HeLa cells

Positive IHC detected in:
human skeletal muscle tissue, human kidney tissue, human renal cell carcinoma tissue, human skeletal muscle tissue

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:100-1:400
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
acetyl-Coenzyme A carboxylase alpha

Calculated molecular weight:
2383aa,275 kDa

Observed molecular weight:
260-270 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ACACA

Synonyms
ACAC, ACACA, ACC, ACC1, ACCA, Acetyl CoA carboxylase 1
Background

ACACA(Acetyl-CoA carboxylase 1, ACC), also named as ACAC, ACC1 and ACCA, belongs to the biotin containing enzyme family. It catalyzes the synthesis of malonyl-CoA, which is an intermediate substrate playing a pivotal role in the regulation of fatty acid metabolism and energy production. ACACA is involved in the biosynthesis of fatty acids, and malonyl-CoA produced is used as a building block to extend the chain length of fatty acids by fatty acid synthase (FAS)(PMID:19900410). It has 4 isoforms produced by alternative promoter usage with the molecular weight between 260 kDa and 270 kDa.


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