AGTR1 Antibody 0 Publications

Mouse Monoclonal| Catalog number: 66415-1-Ig |CloneNo.: 2C5G11

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Freight/Packing

Con: 150 μg/150 μl

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Species specificity:
human, rat, pig, mouse

Positive WB detected in:
pig heart tissue, pig skeletal muscle tissue, rat heart tissue

Positive IHC detected in:
human heart tissue, human heart tissue, human lung cancer tissue

Recommended dilution:
WB : 1:1000-1:4000
IHC : 1:50-1:500

Product Information


Source:
Mouse

Purification method:
Protein A purification

Isotype:
IgG2a

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
angiotensin II receptor, type 1

Calculated molecular weight:
359aa,41 kDa

Observed molecular weight:
50 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
AGTR1

Synonyms
AG2S, AGTR1, AGTR1A, AGTR1B, Angiotensin II type 1 receptor, AT1, AT1AR, AT1B, AT1BR, AT1R, AT2R1, AT2R1A, AT2R1B, HAT1R, Type 1 angiotensin II receptor
Background

Angiotensin II (Ang II), the main effector molecule of the renin-angiotensin system, exerts its actions mainly via interaction with type-1 angiotensin II receptor (AGTR1, also named as AT1R), thereby contributing to blood pressure regulation. AGTR1 mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. By regulating vascular tone, cardiovascular function, salt and water homeostasis, AGTR1 exerts an indispensable physiological role (PMID: 21600887). AGTR1 has been implicated in diverse aspects of human disease, from the regulation of blood pressure and cardiovascular homeostasis to cancer progression (PMID: 26975580).


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