• Featured Product
  • KD/KO Validated

BRCA2 Polyclonal antibody

BRCA2 Polyclonal Antibody for FC, WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, IHC, FC, ELISA

Conjugate

Unconjugated

Cat no : 19791-1-AP

Synonyms

BRCA2, BRCC2, breast cancer 2, early onset, BROVCA2, FACD, FAD, FAD1, FANCB, FANCD, FANCD1



Tested Applications

Positive WB detected inhuman brain tissue, HeLa cells
Positive FC detected inHeLa cells

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:200-1:1000
Sample-dependent, check data in validation data gallery

Product Information

19791-1-AP targets BRCA2 in WB, IHC, FC, ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Cited Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen Peptide
Full Name breast cancer 2, early onset
Calculated molecular weight 384 kDa
Observed molecular weight 384 kDa
GenBank accession numberNM_000059
Gene symbol BRCA2
Gene ID (NCBI) 675
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

BRCA2, also named as FACD and FANCD1, is involved in double-strand break repair and/or homologous recombination. BRCA2 may participate in S phase checkpoint activation. Defects in BRCA2 are a cause of genetic susceptibility to breast cancer (BC) which also called susceptibility to familial breast-ovarian cancer type 2 (BROVCA2).

Protocols

Product Specific Protocols
WB protocol for BRCA2 antibody 19791-1-APDownload protocol
FC protocol for BRCA2 antibody 19791-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
humanWB

J Hematol Oncol

SPAG5 upregulation contributes to enhanced c-MYC transcriptional activity via interaction with c-MYC binding protein in triple-negative breast cancer.

Authors - Ming Li
humanWB

Ann Transl Med

miR-1245a promotes the proliferation and invasion of colon adenocarcinoma by targeting BRCA2.

Authors - Zihao Pan
humanWB,IHC

Cancer Biol Ther

A novel BRCA2 mutation in prostate cancer sensitive to combined radiotherapy and androgen deprivation therapy.

Authors - Qiuli Liu
humanWB

Hum Cell

Flavone protects HBE cells from DNA double-strand breaks caused by PM2.5.

Authors - Xing Ren
humanIHC

Virology

DNA repair gene expression is increased in HPV positive head and neck squamous cell carcinomas.

Authors - Andrew J Holcomb
humanWB

J Cancer

Downregulation of Mitochondrial Single Stranded DNA Binding Protein (SSBP1) Induces Mitochondrial Dysfunction and Increases the Radiosensitivity in Non-Small Cell Lung Cancer Cells.

Authors - You Wang