Tested Applications
| Positive WB detected in | RAW 264.7 cells, mouse brain tissue, rat brain tissue |
Recommended dilution
| Application | Dilution |
|---|---|
| Western Blot (WB) | WB : 1:5000-1:50000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
Product Information
82780-6-RR targets Beta Arrestin 2 in WB, ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Immunogen |
CatNo: Ag0227 Product name: Recombinant human Beta Arrestin 2 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 163-409 aa of BC007427 Sequence: NSVRLVIRKVQFAPEKPGPQPSAETTRHFLMSDRSLHLEASLDKELYYHGEPLNVNVHVTNNSTKTVKKIKVSVRQYADICLFSTAQYKCPVAQLEQDDQVSPSSTFCKVYTITPLLSDNREKRGLALDGKLKHEDTNLASSTIVKEGANKEVLGILVSYRVKVKLVVSRGGDVSVELPFVLMHPKPHDHIPLPRPQSAAPETDVPVDTNLIEFDTNYATDDDIVFEDFARLRLKGMKDDDYDDQLC Predict reactive species |
| Full Name | arrestin, beta 2 |
| Calculated Molecular Weight | 46 kDa |
| Observed Molecular Weight | 47-50 kDa |
| GenBank Accession Number | BC007427 |
| Gene Symbol | Beta Arrestin 2 |
| Gene ID (NCBI) | 409 |
| RRID | AB_3670548 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | P32121 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. |
Background Information
Beta Arrestin 2 is a member of arrestin/beta-arrestin protein family, which are expressed at high levels in the central nervous system (CNS) and play a critical role in the regulation of G-protein coupled receptors (GPCRs) including MOR. Beta Arrestin 2 is an adaptor protein that is important for the regulation of receptors belonging to both dopaminergic and opioid systems. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors.
Protocols
| Product Specific Protocols | |
|---|---|
| WB protocol for Beta Arrestin 2 antibody 82780-6-RR | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
Publications
What published studies show
The Beta Arrestin 2 Recombinant monoclonal antibody (241470F8), catalog number 82780-6-RR, has a total of 1 citation. The cited publication appeared in Clinical and Experimental Pharmacology and Physiology (2025). The research field is cardiovascular pharmacology, specifically investigating how PDZK1 regulates ADRB2 stability and function to prevent vascular remodelling in hypertension.
| Species | Application | Title |
|---|---|---|
Clin Exp Pharmacol Physiol PDZK1 Regulates the Stability and Function of ADRB2 to Prevent Vascular Remodelling in Hypertension. |
