CD146/MCAM Antibody 0 Publications

Mouse Monoclonal| Catalog number: 66153-1-Ig |CloneNo.: 4D8A9

  • Print page
  • Download PDF

Be the first to review this product


-_-

Freight/Packing

Con: 158 μg/150 μl

Choose size:

Please visit your regions distributor:


Species specificity:
human

Positive WB detected in:
A375 cells, HeLa cells, HepG2 cells, L02 cells

Positive IHC detected in:
human placenta tissue, human liver cancer tissue

Positive FC detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:20-1:200

Product Information


Source:
Mouse

Purification method:
Protein G purification

Isotype:
IgG1

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
melanoma cell adhesion molecule

Calculated molecular weight:
646aa,72 kDa

Observed molecular weight:
120 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
MCAM

Synonyms
CD146, MCAM, MUC18
Background

CD146, also known as melanoma cell adhesion molecule (MCAM) or MUC18, originally identified as a biomarker of melanoma progression, is a transmembrane glycoprotein belonging to the immunoglobulin (Ig) superfamily (PMID: 8378324). Structurally, it consists of five Ig domains, a transmembrane domain, and a cytoplasmic region. In normal adult tissue, CD146 is primarily expressed by vascular endothelium and smooth muscle. CD146 is a key cell adhesion protein in vascular endothelial cell activity and angiogenesis, and has been used as marker of circulating endothelium cells (CECs) (PMID: 19356677).


Back
to top