Chk1 Antibody 0 Publications

Mouse Monoclonal| Catalog number: 60277-1-Ig |CloneNo.: 3A3A5

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Freight/Packing

Con: 180 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HeLa cells, human testis tissue, NIH/3T3 cells

Positive IHC detected in:
human small intestine tissue, human small intestine tissue, human testis tissue

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:20-1:200

Product Information


Source:
Mouse

Purification method:
Protein A purification

Isotype:
IgG2b

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
CHK1 checkpoint homolog (S. pombe)

Calculated molecular weight:
54 kDa

Observed molecular weight:
40 kDa,50 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CHEK1

Synonyms
CHEK1, Chk1
Background

CHEK1(Checkpoint kinase-1) is also named as CHK1 and belongs to the protein kinase superfamily. It is implicated in a circuit in which it activates checkpoints, DNA repair and proliferating cell nuclear antigen and FANCD2 monoubiquitinylation(PMID:21389083). CHEK1 protects vertebrate cells against spontaneous chromosome missegregation and is required to sustain anaphase delay when spindle function is disrupted by taxol(PMID:17276342). It has 3 isoforms produced by alternative splicing with the molecular mass of 54 kDa, 44 kDa and 50 kDa.


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