CRB3 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 12315-1-AP

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Freight/Packing

Con: 30 μg/150 μl

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Tested Applications

Applications:
ELISA
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Species specificity:
human

Recommended dilution:

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
crumbs homolog 3 (Drosophila)

Calculated molecular weight:
123aa,13 kDa

Observed molecular weight:

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CRB3

Synonyms
CRB3, crumbs homolog 3 (Drosophila), Crumbs protein homolog 3
Background

Crumbs is an apical transmembrane protein crucial for epithelial morphogenesis in Drosophila melanogaster embryos. Three isoforms of mammalian Crumbs have been identified, and two have been characterized. Crumbs1 (CRB1) is expressed primarily in the central nervous system, whereas Crumbs3 (CRB3) is mainly expressed in epithelial tissues and skeletal muscles. CRB3 is an N-glycosylated, small transmembrane protein. CRB3 has a conserved cytoplasmic domain containing the two motives GTY and ERLI found in Crumbs, but exhibits a very short extracellular domain without the EGF- and laminin A-like G repeats present in the other Crumbs. Through its cytoplasmic domain and its interactors (e.g., Pals1 and Par6), CRB3 plays a role in apical membrane morphogenesis and tight junction regulation. (PMID: 14718572; 12527193; 15976445)


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