CUL2 Antibody 3 Publications

Rabbit Polyclonal| Catalog number: 10981-2-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 20 μg/150 μl

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Species specificity:
human

Positive WB detected in:
HeLa cells

Positive IP detected in:
HeLa cells

Positive IHC detected in:
human prostate cancer tissue, human kidney tissue, human testis tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:200-1:1000
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
cullin 2

Calculated molecular weight:
87 kDa

Observed molecular weight:
87 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CUL2

Synonyms
CUL 2, CUL2, cullin 2
Background

The cullin family proteins are scaffold proteins for the Ring finger type E3 ligases, participating in the proteolysis through the ubiquitin-proteasome pathway. Humans express seven cullin proeins: CUL1–3, CUL4A, CUL4B, CUL5, and CUL7. Each cullin protein can form an E3 ligase similar to the prototype Ring-type E3 ligase Skp1-CUL1-F-box complex. The Cullin-RING-finger type E3 ligases are important regulators in early embryonic development, as highlighted by genetic studies demonstrating that knock-out of CUL1, CUL3, or CUL4A in mice results in early embryonic lethality.


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