CXCL16 Antibody 0 Publications

Mouse Monoclonal| Catalog number: 60123-1-Ig |CloneNo.: 2H7B3

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Freight/Packing

Con: 200 μg/150 μl

Choose size:

Please visit your regions distributor:


Species specificity:
human, mouse

Positive WB detected in:
SH-SY5Y cells

Recommended dilution:
WB : 1:200-1:1000

Product Information


Source:
Mouse

Purification method:
Caprylic acid/ammonium sulfate precipitation

Isotype:
IgG2a

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
chemokine (C-X-C motif) ligand 16

Calculated molecular weight:
273aa,30 kDa

Observed molecular weight:
35 kDa, 60 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CXCL16

Synonyms
C X C motif chemokine 16, CXCL16, CXCLG16, SCYB16, Small inducible cytokine B16, SR PSOX, SRPSOX, Transmembrane chemokine CXCL16
Background

CXCL16 is a recently discovered cytokine belonging to the CXC chemokine family, which is synthesised in plasmacytoid dendritic cell as a transmembrane molecule. It exists in a transmembrane and soluble form. The transmembrane form of CXCL16 functions as an adhesion molecule for CXCR6-expressing cells, whereas the soluble form of CXCL16 mediates infiltration of circulating cells into sites of injury. CXCL16, has been proposed as an important pathogenic mediator in inflammatory diseases, including rheumatoid arthritis, glomerulonephritis, or prostate cancer. CXCL16 has been implicated in some forms of renal disease such as lupus nephritis and antiglomerular basement membrane nephritis. CXCL16 also plays a pivotal role in the pathogenesis of angiotensin II–induced renal injury and fibrosis through regulation of macrophage and T cell infiltration and bone marrow–derived fibroblast accumulation.


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