- Featured Product
- KD/KO Validated
DVL1 Polyclonal Antibody for IHC, WB, ELISA
Cat no : 27384-1-AP
Dishevelled 1, DSH homolog 1, DVL, DVL1
|Positive WB detected in||MCF-7 cells, HEK-293 cells, NIH/3T3 cells, mouse cerebellum tissue|
|Positive IHC detected in||human breast cancer tissue, human prostate cancer tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Western Blot (WB)||WB : 1:500-1:3000|
|Immunohistochemistry (IHC)||IHC : 1:50-1:500|
|Sample-dependent, check data in validation data gallery|
The 27384-1-AP immunogen is Fusion Protein DVL1 protein expressed in E. coli.
|Tested Reactivity||human, mouse|
|Cited Reactivity||human, rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||DVL1 fusion protein Ag26055|
|Full Name||dishevelled, dsh homolog 1 (Drosophila)|
|Calculated molecular weight||75 kDa|
|Observed molecular weight||75 kDa, 73 kDa|
|GenBank accession number||BC050454|
|Gene ID (NCBI)||1855|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.1% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
DVL1 is one of three DVL homologous proteins (DVL1–3) widely expressed in embryonic development and in the adult central nervous system. Dishevelled proteins are a necessary component of the Wnt and planar cell polarity developmental signaling pathways. Overexpression of DVL1 has been linked to prostate and breast cancers through the Wnt signaling pathway.
J Obstet Gynaecol
cDNA expression library screening revealed novel functional genes involved in clear cell carcinogenesis of the ovary in vitro.
Dishevelled-1 regulated apoptosis through NF-κB in cerebral ischemia/reperfusion injury in rats.
Transcription factor AP-4 promotes tumorigenic capability and activates the Wnt/β-catenin pathway in hepatocellular carcinoma.