ERK1/2 Antibody 11 Publications

Rabbit Polyclonal| Catalog number: 11257-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 33 μg/150 μl

Choose size:

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Species specificity:
human, mouse, rat

Positive WB detected in:
HEK-293 cells, HepG2/A431 cells , HeLa cells, A375 cells, HepG2 cells, A549 cells, Jurkat cells, mouse lung tissue

Positive IHC detected in:
human colon cancer tissue, human breast cancer tissue, human colon cancer tissue, human prostate cancer tissue, human prostate hyperplasia tissue

Positive IF detected in:
A375 cells, MCF-7 cells, PC-3 cells

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:100-1:400
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
mitogen-activated protein kinase 3

Calculated molecular weight:
44 kDa

Observed molecular weight:
38-44 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
MAPK3

Synonyms
ERK, ERK 1, ERK1, ERK1/2, ERT2, HS44KDAP, HUMKER1A, Insulin stimulated MAP2 kinase, MAP kinase 1, MAP kinase 3, MAP kinase isoform p44, MAPK 1, MAPK 3, MAPK3, p44 ERK1, p44 MAPK, P44ERK1, P44MAPK, PRKM3
Background

ERK1 and ERK2 belongs to the protein kinase superfamily. It is involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK-1. ERK1/2 catalized the reaction: ATP + a protein = ADP + a phosphoprotein. It is activated by tyrosine phosphorylation in response to insulin and NGF. This antibody can recognize both ERK1 and ERK2.


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