• Featured Product
  • KD/KO Validated

FLCN Polyclonal antibody

FLCN Polyclonal Antibody for WB,ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IP, IHC,ELISA

Conjugate

Unconjugated

Cat no : 11236-2-AP

Synonyms

BHD, FLCL, FLCN, folliculin



Tested Applications

Positive WB detected inA431 cells, HEK-293 cells, HeLa cells, NCCIT cells

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:500-1:1000
Sample-dependent, check data in validation data gallery

Product Information

11236-2-AP targets FLCN in WB, IP, IHC,ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivityhuman, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen FLCN fusion protein Ag1746
Full Name folliculin
Calculated molecular weight 38 kDa
Observed molecular weight64-75 kDa
GenBank accession numberBC015687
Gene symbol FLCN
Gene ID (NCBI) 201163
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

FLCN, also named as BHD, belongs to the folliculin family. It may play a role in the pathogenesis of an uncommon form of kidney cancer through its association with an inherited disorder of the hair follicle (fibrofolliculomas). FLCN may be a tumor suppressor. It is involved in colorectal tumorigenesis. It may be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. Mutation of FLCN may cause the BHD(Birt-Hogg-Dube syndrome ) or (PSP) primary spontaneous pneumothorax. And it may be involved in renal cell carcinoma.

Protocols

Product Specific Protocols
WB protocol for FLCN antibody 11236-2-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
humanWB

Biochem Biophys Res Commun

Stabilization of MAPO1 by specific binding with folliculin and AMP-activated protein kinase in O?-methylguanine-induced apoptosis.

Authors - Sano Shiori S
  • KD Validated
WB

J Trace Elem Med Biol

Methionine-chelated Zn promotes anabolism by integrating mTOR signal and autophagy pathway in juvenile yellow catfish.

Authors - Kun Wu
humanIHC

Front Mol Biosci

FLCN Regulates HIF2α Nuclear Import and Proliferation of Clear Cell Renal Cell Carcinoma.

Authors - Xuyang Zhao
mouseWB

DNA Repair (Amst)

Activation of AMP-activated protein kinase by MAPO1 and FLCN induces apoptosis triggered by alkylated base mismatch in DNA.

Authors - Lim Teik How TH
  • KD Validated
mouseWB,IP

FASEB J

AMPK promotes induction of the tumor suppressor FLCN through activation of TFEB independently of mTOR.

Authors - Caterina Collodet