Back

GPR37/Pael-R Antibody 5 Publications

Rabbit Polyclonal| Catalog number: 14820-1-AP

Featured Product KD/KO validated

  • Print page
  • Download PDF

Be the first to review this product

-_-

Freight/Packing

Con: 47 μg/150 μl

Choose size:

Please visit your regions distributor:

Request quote for
bulk/custom formulations

Special offer: Add control/tag antibody for $99
Load more

Tested Applications

Applications:
WB, IF, ELISA
Application not tested? Please see our Guarantee


Images See all

GPR37/Pael-R Antibody WB mouse brain tissue 14820-1-AP

mouse brain tissue were subjected to SDS PAGE followed by western blot with 14820-1-AP(GPR37/Pael-R antibody) at dilution of 1:1600 incubated at room temperature for 1.5 hours

Species specificity:
human, mouse, rat
Positive WB detected in:
mouse brain tissue
Recommended dilution:
WB : 1:500-1:3200
Sample-dependent, check data in Validation tab

Protocols

Product-specific protocols

Standard Protocols

Product Information

Source:
Rabbit
Purification method:
Antigen affinity purification
Isotype:
IgG
Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Immunogen:
GPR37/Pael-R fusion protein Ag6591
Full name:
G protein-coupled receptor 37 (endothelin receptor type B-like)
Calculated molecular weight:
67 kDa
Observed molecular weight:
50-55 kDa
GenBank accession number:
BC040007
Gene ID (NCBI):
2861
Gene symbol
GPR37
Synonyms
EDNRBL, ETBR LP 1, GPR37, hET(B)R LP, PAELR, Pael-R

Background

The orphan G protein-coupled receptor GPR37, also known as PAELR (parkin-associated endothelin receptor-like receptor) or ETBR-LP-1 (endothelin B receptor-like protein 1), is a 613 aa, multi-pass membrane protein predominantly expressed in the brain. It is a substrate of parkin (PARK2). When overexpressed in cells, GPR37 tends to become insoluble, unfolded, and ubiquitinated in vivo. Accumulation of the unfolded protein may lead to dopaminergic neuronal death in juvenile Parkinson disease (JPD). This antibody recognizes endogenous GPR37, which migrates as an approximately 50-55 kDa band in SDS-PAGE (PMID:17519329).


Back
to top