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GPR37/Pael-R Antibody 4 Publications

Rabbit Polyclonal| Catalog number: 14820-1-AP

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Tested Applications
Applications:
ELISA, IF, WB
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14820-1-AP;mouse brain tissue

mouse brain tissue were subjected to SDS PAGE followed by western blot with 14820-1-AP(GPR37/Pael-R antibody) at dilution of 1:1600 incubated at room temperature for 1.5 hours

Species specificity:
human, mouse, rat
Positive WB detected in:
mouse brain tissue
Recommended dilution:
WB : 1:500-1:3200

Product Information

Source:
Rabbit
Purification method:
Antigen affinity purification
Isotype:
IgG
Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Immunogen:
GPR37/Pael-R fusion protein Ag6591
Full name:
G protein-coupled receptor 37 (endothelin receptor type B-like)
Calculated molecular weight:
67 kDa
Observed molecular weight:
50-55 kDa
GenBank accession number:
BC040007
Gene ID (NCBI):
2861
Gene symbol
GPR37
Synonyms
EDNRBL, ETBR LP 1, GPR37, hET(B)R LP, PAELR, Pael-R
Background

The orphan G protein-coupled receptor GPR37, also known as PAELR (parkin-associated endothelin receptor-like receptor) or ETBR-LP-1 (endothelin B receptor-like protein 1), is a 613 aa, multi-pass membrane protein predominantly expressed in the brain. It is a substrate of parkin (PARK2). When overexpressed in cells, GPR37 tends to become insoluble, unfolded, and ubiquitinated in vivo. Accumulation of the unfolded protein may lead to dopaminergic neuronal death in juvenile Parkinson disease (JPD). This antibody recognizes endogenous GPR37, which migrates as an approximately 50-55 kDa band in SDS-PAGE (PMID:17519329).


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