GSK3B Antibody 40 Publications

Rabbit Polyclonal| Catalog number: 22104-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 62 μg/150 μl

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Species specificity:
human, mouse, rat, hamster, pig

Positive WB detected in:
mouse brain tissue, HeLa cells, LNCaP cells, mouse brain tissue, mouse kidney tissue, mouse ovary tissue, mouse testis tissue, mouse thymus tissue, PC-3 cells, rat brain tissue

Positive IP detected in:
mouse brain tissue

Positive IHC detected in:
human lung cancer tissue, human lung cancer tissue, human prostate hyperplasia tissue, human testis tissue

Positive IF detected in:
MCF-7 cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:100-1:400
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
glycogen synthase kinase 3 beta

Calculated molecular weight:
433aa,48 kDa

Observed molecular weight:
46-48 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
GSK3B

Synonyms
GSK 3 beta, GSK3 beta, GSK3A B, GSK3B, GSK-3B, GSK3B 216P, gsk3beta
Background

Glycogen synthase kinase-3 (GSK3) is a proline-directed serine-threonine kinase that was initially identified as a phosphorylating and inactivating glycogen synthase .GSK3B is involved in energy metabolism, neuronal cell development, and body pattern formation.In skeletal muscle, it contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Researches showed that the crystal structure of human GSK3B, expressed in insect cells, at 2.8-angstrom resolution .This antibody recognize the C-terminal of GSK3B.


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