IFITM1-Specific Antibody 17 Publications

Mouse Monoclonal| Catalog number: 60074-1-Ig |CloneNo.: 5B5E2

Featured Product KD/KO validated

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Freight/Packing

Con: 60 μg/150 μl

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Species specificity:
human, virus

Positive WB detected in:
K-562 cells, HeLa cells, HepG2 cells

Positive IP detected in:
HepG2 cells

Positive IHC detected in:
human lymphoma tissue

Recommended dilution:
WB : 1:5000-1:50000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:200-1:1000

Product Information


Source:
Mouse

Purification method:
Caprylic acid/ammonium sulfate precipitation

Isotype:
IgG2a

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
interferon induced transmembrane protein 1 (9-27)

Calculated molecular weight:

Observed molecular weight:
14kd; 17 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
IFITM1

Synonyms
9 27, CD225, IFI17, IFITM1, Interferon induced protein 17, Leu 13 antigen, LEU13
Background

IFITM1(interferon induced transmembrane protein), also named DSPA2a and interferon-induced protein 17 (IFI17), belongs to the CD225 family. It has two transmembrane domain and serves as an IFN-induced antiviral protein that mediates cellular innate immunity to at least three major human pathogens, influenza A H1N1 virus, West Nile virus (WNV), and dengue virus , by inhibiting the early steps of replication. IFITM proteins are recently identified as viral restriction factors that inhibit infection mediated by the influenza A virus (IAV) hemagglutinin (HA) protein. Also they serve as important components of the innate immune system to restrict HIV-1 infection. 60074-1-Ig is a mouse monoclonal antibody which specifically recognizing IFITM1 but not IFITM2 or IFITM3.


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