MMP9 (N-terminal) Antibody 107 Publications

Rabbit Polyclonal| Catalog number: 10375-2-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 41 μg/150 μl

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Species specificity:
human, mouse, rat, zebrafish, rabbit

Positive WB detected in:
Jurkat cells, NIH/3T3 cells

Positive IP detected in:
Jurkat cells

Positive IHC detected in:
human breast cancer tissue, human breast cancer tissue, human cervical cancer tissue, human stomach cancer tissue, human tonsillitis tissue, mouse heart tissue

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
IHC : 1:100-1:1000
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)

Calculated molecular weight:
707aa,78 kDa

Observed molecular weight:
67 kDa, 92 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
MMP9

Synonyms
92 kDa gelatinase, 92 kDa type IV collagenase, CLG4B, Gelatinase B, GELB, Matrix metalloproteinase 9, MMP 9, MMP9
Background

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. Matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (MMP9, synonyms: GELB, CLG4B) degrades type IV and V collagens. Studies in rhesus monkeys suggest that MMP9 is involved in IL-8-induced mobilization hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. The pro-MMP9 is 92 kDa and it can be detected a processed form of 68 kDa or 82 kDa and this protein can exsit as a dimer of 180 kDa(PMID:7492685).


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