NF-M-Specific Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 20664-1-AP

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Freight/Packing

Con: 52 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
mouse brain tissue, rat brain tissue, human brain tissue

Positive IP detected in:
rat brain tissue

Positive IHC detected in:
human brain tissue, human brain tissue, rat brain tissue

Positive IF detected in:
SH-SY5Y cells

Recommended dilution:
WB : 1:500-1:3000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:50-1:500
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
neurofilament, medium polypeptide

Calculated molecular weight:
102 kDa

Observed molecular weight:
140-160 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
NEFM

Synonyms
NEF3, NEFM, NF M, NFM
Background

NEFM, also named as NEF3 and NFM, belongs to the intermediate filament family. Neurofilaments are the 10nm intermediate filaments found specifically in neurons. They are a major component of the cell's cytoskeleton, and provide support for normal axonal radial growth. Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. The names given to the three major neurofilament subunits are based upon the apparent molecular weight of the mammalian subunits on SDS-PAGE:NF-L, 65-68kd; NF-M,145-160kd and NF-H, 200-220kd.The antibody is specific to NEFM.


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