IkB alpha Antibody 39 Publications

Rabbit Polyclonal| Catalog number: 10268-1-AP

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Freight/Packing

Con: 24 μg/150 μl

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Species specificity:
human, mouse, pig, A. sphaerocephala Krasch, rat

Positive WB detected in:
Jurkat cells, A431 cells, HEK-293 cells, HeLa cells, HL-60 cells, mouse liver tissue, NIH/3T3 cells, pig liver tissue

Positive IP detected in:
HeLa cells

Positive IHC detected in:
human kidney tissue, human kidney tissue, human ovary tumor tissue, human prostate cancer tissue, human stomach tissue

Positive IF detected in:
HeLa cells

Positive FC detected in:
HeLa cells, NIH/3T3 cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:50-1:500
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha

Calculated molecular weight:
39 kDa

Observed molecular weight:
36-40 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
NFKBIA

Synonyms
I kappa B alpha, IkappaBalpha, IkB alpha, IKBA, MAD 3, MAD3, NF kappa B inhibitor alpha, NFKBI, NFKBIA
Background

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (NFKBIA, synonyms: IKBA, MAD-3, NFKBI). NFKB1 or NFKB2 is bound to REL, RELA , or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime.


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