Biotin OPTN Antibody 0 Publications

Mouse Monoclonal| Catalog number: Biotin-60293

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Freight/Packing

Con: 170 μg/150 μl

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Species specificity:
human

Positive WB detected in:
human brain

Recommended dilution:
WB : 1:500-1:2000

Product Information


Source:
Mouse

Purification method:
Protein G purification

Isotype:
IgG1

Storage:
PBS(10mM), with 50% glycerol, without sodium azide. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
optineurin

Calculated molecular weight:
66 kDa

Observed molecular weight:
70-74 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
OPTN

Synonyms
FIP 2, optineurin, OPTN
Background

OPTN, also named as FIP2, GLC1E, HIP7, HYPL and NRP, plays a neuroprotective role in the eye and optic nerve. It is probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. OPTN may act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). OPTN may constitute a cellular target for adenovirus E3 14.7, an inhibitor of TNF-alpha functions, thereby affecting cell death. Defects in OPTN are the cause of primary open angle glaucoma type 1E (GLC1E). Defects in OPTN are a cause of susceptibility to normal pressure glaucoma (NPG). OPTN mutated in adult-onset primary open angle glaucoma. It supports the protective role of OPTN in the trabecular meshwork. This antibody is conjugated with Biotin.


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