PAX8 Polyclonal Antibody for IHC, WB, ELISA
Host / Isotype
Rabbit / IgG
WB, IHC, ELISA
Cat no : 22255-1-AP
paired box 8, Paired box protein Pax 8, PAX8
|Sample-dependent, check data in validation data gallery|
The 22255-1-AP immunogen is Fusion Protein PAX8 protein expressed in E. coli.
|Host / Isotype||Rabbit / IgG|
|Immunogen||PAX8 fusion protein Ag17759|
|Full Name||paired box 8|
|Calculated molecular weight||450aa,48 kDa|
|Observed molecular weight|
|GenBank accession number||BC001060|
|Gene ID (NCBI)||7849|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
PAX8 is a member of the paired box (PAX) family of transcription factors, typically containing a paired box domain and a paired-type homeodomain. It is expressed during organogenesis of the thyroid gland, kidney and Mullerian system. It is thought to regulate the expression of Wilms tumor suppressor (WT1) gene and mutations in PAX8 have been associated with Wilms tumor cells, thyroid and ovarian carcinomas. PAX8 is a useful marker in distinguishing ovarian carcinomas from mammary carcinomas (PMID: 18724243). PAX8 is expressed in a high percentage of ovarian serous, endometrioid, and clear cell carcinomas, but only rarely in primary ovarian mucinous adenocarcinomas.
PAX8 has 5 isoforms with calculated MW 31kd, 34kd, 41kd, 43kd and 48kd. And there is a 60kd band corresponding to the electrophoretic mobility of PAX8 (PMID:15650356). Proteintech’s 10336-1-AP antibody has cross-reactivities with the other PAX family members.